' 
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
8
Vitamin D3 shows promise for knee OA
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
Direct focus on vitamin D effectiveness
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Read More
9
Fish oil improves knee function
Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.
Highly relevant to knee osteoarthritis
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
9
DHA alleviates knee arthritis pain
Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis.
Study directly assesses DHA's effect
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
Most Useful Reviews
8.8
Reduced knee pain
My husband's rheumatologist suggested Carlson Vitamin D several years ago. He asked if I had arthritis, which I do, and recommended I try it too. I have noticed a difference in my knee pain and have shared this vitamin with friends.
Read More
7.5
Improved knee pain
It's great for daily use, and I have genuinely improved my vitamin D levels, which has helped with my joint pains.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7
- All Researches
9
Vitamin D alleviates knee pain
Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression.
Strong relevance to knee OA
We focused on the effects of vitamin D (VITD) in reducing knee pain linked to osteoarthritis (OA) using a study conducted on Wistar rats. The rats were induced with OA through a combination of surgical methods known as ACLT (anterior cruciate ligament transection) along with medial meniscectomy. This allowed us to closely observe the direct impact of VITD on pain levels and cartilage health.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Read More
9
Omega-3 improves knee pain relief
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Significant pain reduction observed
We conducted a compelling study to investigate how docosahexaenoic acid (DHA), often found in omega-3 supplements, influences knee pain in individuals aged 40 and older. The research was carefully designed as a randomized, double-blind, controlled clinical trial with four groups over an 8-week period. The participants dealt with persistent knee discomfort, scoring more than 3 on a visual analog scale for pain.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
Read More
9
Fish oil improves knee function
Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.
Highly relevant to knee osteoarthritis
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
9
DHA alleviates knee arthritis pain
Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis.
Study directly assesses DHA's effect
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Study explores combined supplement effects
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Reduced knee pain
My husband's rheumatologist suggested Carlson Vitamin D several years ago. He asked if I had arthritis, which I do, and recommended I try it too. I have noticed a difference in my knee pain and have shared this vitamin with friends.
7.5
Improved knee pain
It's great for daily use, and I have genuinely improved my vitamin D levels, which has helped with my joint pains.
